20L Double Layer Reactor

What is it?

The double jacketed glass reactor — also known as double layer reactor — is a large-capacity temperature-controlled stirred vessel engineered for pilot-scale, production-scale validation, and full process scale-up in chemical synthesis, pharmaceutical manufacturing, and fine chemical development. This 20L model features a 20L material capacity inner vessel made of high-borosilicate glass, with a 7.6L mezzanine jacket for efficient heating and cooling circulation. It provides precise temperature management, robust variable-speed stirring, and highly flexible configurations, making it suitable for vacuum, reflux, continuous reactions, distillation, crystallization, and more.

Most suitable laboratories and project stages

• Pharmaceutical pilot and production-scale labs
• Chemical process development and scale-up centers
• Technology transfer and industrial amplification laboratories
• Application-oriented R&D labs with production goals
• Contract manufacturing organizations (CMO) and pilot facilities
• Research institutes focused on large-scale process validation

What scale-up pain points does it solve for you?

• Small-to-medium scale data fails to predict full production behavior, causing repeated failures and expensive re-engineering
• Pronounced amplification effects in heat transfer, mass transfer, shear forces, dead zones, and local overheating at production volumes
• Poor long-term stability, batch-to-batch variability, and reproducibility in continuous or extended operations
• Loss of control over crystallization, precipitation, and crystal form at scale, impacting purity, yield, and product quality
• Increased safety risks with exothermic reactions, flammable solvents, or corrosive media during large-scale processing
• Insufficient reliable design basis for industrial reactors, leading to late-stage rework, delays, and high costs
• Challenges in producing sufficient sample quantities for commercial trials, stability studies, or customer validation

Core technical features (why these parameters matter for scale-up)

• 20L material capacity + 7.6L mezzanine jacket — Large heat exchange area for realistic thermal simulation at production-like scale
• -120°C to +300°C ultra-wide temperature range — Supports extreme gradients and precise control under amplified conditions
• Fluorine-coated stainless steel stirring paddle — High corrosion resistance for aggressive media in large volumes
• 0–450 rpm powerful adjustable stirring — High-torque output simulates industrial mixing and shear forces
• 6 customizable ports + 1L constant pressure funnel — Enables continuous feeding, multi-point monitoring, vacuum/reflux, and complex setups
• Large 260mm coverage diameter — Minimizes dead zones and enhances mixing uniformity at scale
• High-borosilicate double-walled structure — Transparent for real-time observation of scale-up effects + effective insulation
• Optional explosion-proof motor & control box — Critical safety for hazardous production-scale operations

Typical scale-up validation experiments

• Full process scale-up verification (Lab → Pilot → Production)
• Continuous / long-duration reaction stability testing (hours to days)
• Large-scale crystallization, precipitation, and polymorph control
• Heat/mass transfer and stirring/shear amplification studies
• Validation of thermally sensitive or highly exothermic/endothermic reactions
• Multi-batch reproducibility and robustness testing
• Production-scale sample preparation for commercial trials and customer validation
• Generation of design basis data for industrial reactors

Why choose 20L and above capacity?

• Much closer to real production conditions — Heat transfer, mass transfer, and shear effects become dominant
• Can validate critical scale-up parameters — Temperature gradients, power consumption, local overheating, crystallization behavior
• Provides reliable design basis for industrial reactors — More credible parameters, material balance, and energy estimates
• Ideal for commercial demos & large sample preparation — Quickly produces kilogram-scale quantities for validation and approval
• Strong data reproducibility — Higher batch-to-batch consistency, significantly reduces production risks and costs

Recommended Compatible Equipment

• Recirculating Chiller — Stable low-temperature fluid for the mezzanine jacket
• Heating Circulator — Precise high-temperature applications up to 300°C
• Vacuum Pump — Reduced-pressure reactions and solvent removal
• Reflux Condenser — Efficient distillation and reflux under controlled conditions
• Temperature Controller — High-accuracy PID regulation across the process

Demo Video & More Options See the full installation, temperature control, stirring, feeding, and cleaning process in action: Watch product operation demo video

Looking for other volumes or configurations? Browse the complete Double Jacketed Glass Reactor Series — including 1L to 200L and beyond.

Need custom port configuration, specialized stirring, explosion-proof upgrades, or scale-up consultation? Contact us for professional recommendations and quotations.